Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12362192 | 0.90 | REN (0.46) | RENHTTPPARGTSHRLMNA | |
| SCHEMBL14747749 | 0.87 | REN (0.47) | RENPPARGTSHRNPSR1THRB | |
| SCHEMBL5987087 | 0.84 | TSHR (0.44) | RENHTTPPARGTSHRLMNA | |
| SCHEMBL13434133 | 0.80 | TSHR (0.61) | RENHTTTSHRLMNAUSP2 | |
| SCHEMBL14747754 | 0.75 | REN (0.50) | REN | |
| SCHEMBL7636421 | 0.75 | REN (0.53) | RENTSHRNPSR1THRBALDH1A1 | |
| SCHEMBL7603116 | 0.72 | TSHR (0.47) | HTTTSHRLMNAUSP2MAPK1 | |
| SCHEMBL5987076 | 0.72 | REN (0.49) | RENPPARGTSHRNPSR1THRB | |
| SCHEMBL5986192 | 0.70 | REN (0.48) | RENHTTTSHRNPSR1THRB | |
| SCHEMBL7634836 | 0.70 | REN (0.48) | RENTSHRNPSR1THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389511-B2 | Bicyclic heterocyclic derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | disclosed |