Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.30 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.30 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12361722 | 0.90 | REN (0.56) | RENCYP2D6CYP2C9CYP3A4MTOR | |
| SCHEMBL5985387 | 0.85 | REN (0.52) | RENCYP2D6CYP2C9CYP3A4MTOR | |
| SCHEMBL7638870 | 0.85 | REN (0.52) | RENCYP2D6CYP2C9CYP3A4MTOR | |
| SCHEMBL5984677 | 0.85 | REN (0.52) | RENCYP2D6CYP2C9CYP3A4MTOR | |
| SCHEMBL5984244 | 0.82 | REN (0.49) | RENCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5984245 | 0.81 | REN (0.57) | RENCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL13433998 | 0.80 | REN (0.60) | RENCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL2241757 | 0.78 | REN (0.60) | RENCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5985373 | 0.77 | REN (0.57) | RENCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL27801669 | 0.76 | REN (0.56) | RENCYP2D6CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389511-B2 | Bicyclic heterocyclic derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | disclosed |