Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.31 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12361722 | 0.92 | REN (0.56) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL7606441 | 0.89 | REN (0.39) | RENCYP2D6CYP2C9ALDH1A1RAB9A | |
| SCHEMBL5984674 | 0.87 | REN (0.52) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL7638870 | 0.87 | REN (0.52) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5984677 | 0.87 | REN (0.52) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL14747754 | 0.85 | REN (0.50) | RENCYP2D6CYP2C9CYP3A4MTOR | |
| SCHEMBL5985379 | 0.84 | REN (0.49) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5984244 | 0.84 | REN (0.49) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL13433998 | 0.82 | REN (0.60) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL2241757 | 0.80 | REN (0.60) | RENCYP2D6CYP2C9CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658639-B2 | N-substituted-cyclic amino derivative | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2014-02-25 | — | — | US | disclosed |
| US-20120122773-A1 | N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| EP-2447264-A1 | N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010150840-A1 | N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122773-A1 | N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE | REN, AGTR1, AGTR2 | REN 1/4885CYP2D6 218/4885CYP2C9 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.