Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067214 | 0.81 | NPSR1 (0.52) | ALDH1A1TDP1POLBSMN1; SMN2RAB9A | |
| SCHEMBL12353505 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL2243689 | 0.78 | FBP1 (0.38) | ALDH1A1TDP1POLBSMN1; SMN2MEN1 | |
| SCHEMBL1616513 | 0.77 | ALDH1A1 (0.69) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL16958356 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL11233959 | 0.74 | ALDH1A1 (0.60) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL12362379 | 0.74 | ALDH1A1 (0.47) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL16606884 | 0.74 | KMT2A (0.53) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL983421 | 0.73 | ALDH1A1 (0.58) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL983417 | 0.73 | ALDH1A1 (0.58) | ALDH1A1TDP1HPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389511-B2 | Bicyclic heterocyclic derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | disclosed |