Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18160868 | 0.82 | MAPT (0.44) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL11517565 | 0.76 | MAPT (0.55) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL12662873 | 0.71 | KDM4E (0.40) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL9445166 | 0.69 | MAPT (0.74) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL3631370 | 0.69 | MAPT (0.53) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL19623828 | 0.68 | MAPT (0.36) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| SCHEMBL27793746 | 0.66 | LMNA (0.43) | MAPTHTTTP53SMN1; SMN2KMT2A | |
| SCHEMBL12618683 | 0.66 | CYP11B1 (0.46) | MAPTHTTTP53KMT2AMEN1 | |
| SCHEMBL6436512 | 0.65 | MAPT (0.42) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Ethylene SCHEMBL10418999 | 0.63 | MAPT (0.35) | MAPTHTTTP53STAT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |