Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PRCP | P42785 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12183983 | 0.92 | PRCP (0.64) | KMT2AMEN1PRCPMAPK1SYK | |
| SCHEMBL14749287 | 0.86 | PRCP (0.72) | KMT2AMEN1PRCPSYKKDM4E | |
| SCHEMBL14686464 | 0.83 | PRCP (0.76) | KMT2AMEN1PRCPMAPK1SYK | |
| SCHEMBL14749316 | 0.83 | PRCP (0.57) | PRCPMAPK1KDM4EMAP3K12PDE2A | |
| SCHEMBL14749333 | 0.82 | PRCP (0.59) | KMT2AMEN1PRCPMAPK1KDM4E | |
| SCHEMBL14749335 | 0.81 | PRCP (0.64) | KMT2APRCPKDM4EPDE2A | |
| SCHEMBL14749338 | 0.80 | PRCP (0.65) | KMT2APRCPSYKKDM4ESMN1; SMN2 | |
| SCHEMBL12184064 | 0.79 | PRCP (0.83) | PRCPSYKKDM4ESMN1; SMN2 | |
| SCHEMBL14749320 | 0.78 | PRCP (0.58) | PRCPMAPK1SYKKDM4EMAP3K12 | |
| SCHEMBL14701329 | 0.77 | PRCP (0.86) | PRCPSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, ENPEP | KMT2A 2172/4885MEN1 3238/4885PRCP 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.