Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 6/20 | 0.86 |
| ▸ | SYK | P43405 | 8/20 | 0.50 |
| ▸ | RBP4 | P02753 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686541 | 0.92 | PRCP (1.00) | PRCPSYKRBP4CNR1GRM5 | |
| SCHEMBL14749287 | 0.91 | PRCP (0.72) | PRCPSYKRBP4CNR1 | |
| SCHEMBL12184064 | 0.84 | PRCP (0.83) | PRCPSYKRBP4CNR1 | |
| SCHEMBL17826599 | 0.81 | PRCP (0.80) | PRCPCNR1GRM5 | |
| SCHEMBL14686430 | 0.81 | PRCP (0.76) | PRCP | |
| SCHEMBL12185618 | 0.79 | PRCP (0.69) | PRCPSYKRBP4CNR1 | |
| SCHEMBL14686464 | 0.79 | PRCP (0.76) | PRCPSYK | |
| SCHEMBL14749285 | 0.77 | KMT2A (0.55) | PRCPSYK | |
| SCHEMBL12185519 | 0.76 | PRCP (0.71) | PRCPSYKRBP4CNR1GRM5 | |
| SCHEMBL14749316 | 0.74 | PRCP (0.57) | PRCPGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, ENPEP | PRCP 1/4885SYK 4846/4885RBP4 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.