Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 6/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.49 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.49 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.49 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.49 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.49 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.49 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.49 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.49 |
| ▸ | CACNA2D4 | Q7Z3S7 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686708 | 0.85 | PRCP (0.65) | PRCPMEN1KMT2AKDM4EMAPT | |
| SCHEMBL14736412 | 0.81 | PRCP (0.53) | PRCPGPR119LMNA | |
| SCHEMBL14749302 | 0.81 | PRCP (0.48) | PRCPCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL14686594 | 0.81 | PRCP (0.60) | PRCPKDM4EMAPTCNR1 | |
| SCHEMBL16827791 | 0.77 | MEN1 (0.60) | PRCPMEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL12186022 | 0.75 | PRCP (0.68) | PRCP | |
| SCHEMBL12185548 | 0.75 | HTT (0.79) | MEN1HPGDKMT2AHSD17B10USP2 | |
| SCHEMBL15824692 | 0.75 | HTT (0.51) | GPR119MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL12185513 | 0.74 | PRCP (0.62) | PRCPMEN1KMT2AKDM4E | |
| SCHEMBL16827821 | 0.74 | MEN1 (0.60) | PRCPMEN1HPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2568812-B1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2568812-B1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-10-26 | — | — | EP | disclosed |
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2568812-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2011143057-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, ENPEP | PRCP 1/4885GPR119 247/4885CACNB4 4809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.