Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.37 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13354410 | 0.77 | HPGDS (0.42) | HPGDSBACE1CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL12648428 | 0.77 | NOTUM (0.50) | HPGDSCHRNA7CHRNA10CHRNA9GLRA3 | |
| SCHEMBL8239613 | 0.75 | LTA4H (0.50) | HPGDSCHRNA7CHRNA10CHRNA9LTA4H | |
| SCHEMBL13466616 | 0.74 | HPGDS (0.42) | HPGDSBACE1CCNCCDK8GLRA3 | |
| SCHEMBL19156716 | 0.73 | HPGDS (0.39) | HPGDSBACE1CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL14752258 | 0.73 | HPGDS (0.39) | HPGDSBACE1CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL13086678 | 0.73 | HPGDS (0.39) | HPGDSBACE1CHRNA7CHRNA10CHRNA9 | |
| Hydrochloric Acid SCHEMBL30555492 | 0.72 | HPGDS (0.41) | HPGDSBACE1CCNCCDK8GLRA3 | |
| SCHEMBL13177775 | 0.72 | CYP1A1 (0.45) | BACE1GPR55CYP11B2PRMT5WDR77 | |
| SCHEMBL13737200 | 0.70 | HPGDS (0.53) | HPGDSBACE1CHRNA7CHRNA10CHRNA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059835-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059835-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | PIK3CA, PIK3CD, PIK3CB | HPGDS 228/4885BACE1 2873/4885CHRNA7 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.