Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.62 |
| ▸ | HPGD | P15428 | 8/20 | 0.62 |
| ▸ | GAA | P10253 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | GLA | P06280 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15984892 | 0.86 | KDM4E (0.74) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL14756756 | 0.82 | KDM4E (0.58) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL11066632 | 0.77 | KDM4E (0.61) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL6991771 | 0.75 | KDM4E (0.62) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL18155873 | 0.74 | KDM4E (0.67) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL11313571 | 0.74 | KDM4E (0.66) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL6799411 | 0.74 | KDM4E (0.57) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL12988158 | 0.73 | KDM4E (0.79) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL12987943 | 0.72 | KDM4E (0.65) | KDM4EHPGDGAAHSD17B10KMT2A | |
| SCHEMBL6993105 | 0.72 | KDM4E (0.73) | KDM4EHPGDGAAHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015081280-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| WO-2013033268-A2 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |