Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.75 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757390 | 0.86 | MAPT (1.00) | MAPTLMNAL3MBTL1TDP1RAB9A | |
| SCHEMBL14434517 | 0.82 | MAPT (0.77) | MAPTLMNAL3MBTL1TDP1HTT | |
| SCHEMBL9925199 | 0.82 | MAPT (0.77) | MAPTLMNAL3MBTL1TDP1HTT | |
| SCHEMBL12218020 | 0.82 | MAPT (0.77) | MAPTLMNAL3MBTL1TDP1HTT | |
| SCHEMBL9655956 | 0.76 | MAPT (0.63) | MAPTLMNARAB9ANPC1GAA | |
| SCHEMBL9655953 | 0.76 | MAPT (0.63) | MAPTLMNARAB9ANPC1GAA | |
| SCHEMBL31005089 | 0.74 | MAPT (0.78) | MAPTLMNAL3MBTL1RAB9ANPC1 | |
| SCHEMBL10335322 | 0.73 | MAPT (0.63) | MAPTLMNARAB9ANPC1GAA | |
| SCHEMBL1223595 | 0.72 | TRPM5 (1.00) | MAPTLMNAHTTGAAPOLB | |
| SCHEMBL1223594 | 0.72 | TRPM5 (1.00) | MAPTLMNAHTTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013032907-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER STEM CELLS | THE BROAD INSTITUTE, INC. (US) | 2013-03-07 | — | — | WO | disclosed |