Diotyrosine

Diotyrosine

SCHEMBL147579

N[C@@H](Cc1cc(I)c(O)c(I)c1)C(=O)O

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT5 Q9NXA8 1/20 0.82
THRB P10828 8/20 0.75
THRA P10827 6/20 0.75
MEN1 O00255 5/20 0.75
KMT2A Q03164 5/20 0.75
LMNA P02545 4/20 0.75
PPARG P37231 4/20 0.75
TTR P02766 2/20 0.75
ADORA3 P0DMS8 2/20 0.75
PDE4D Q08499 2/20 0.75
HSD17B10 Q99714 2/20 0.75
NR1I2 O75469 2/20 0.75
NR3C1 P04150 1/20 0.75
CYP1A2 P05177 1/20 0.75
HTR1A P08908 1/20 0.75
CYP2C9 P11712 1/20 0.75
TBXA2R P21731 1/20 0.75
NTSR1 P30989 1/20 0.75
HTR2B P41595 1/20 0.75
USP2 O75604 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diotyrosine SCHEMBL147578 1.00 SIRT5 (0.82) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL838215 1.00 SIRT5 (0.82) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL31135680 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL14484740 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL5801627 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL1741366 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL31135662 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL28737936 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL16416106 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL28737934 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4151 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
US-20260049178-A1 CROSSLINKING AGENTS AND MEDICAL HYDROGELS FORMED THEREFROM BOSTON SCIENTIFIC SCIMED, INC. (US) 2026-02-19 US claimed
US-12546788-B2 Methods for differentiating destructive thyroiditis from other pathological conditions ASKA PHARMACEUTICAL CO., LTD. (JP) 2026-02-10 US claimed
US-12540403-B2 Stable composition for catalytic deposition of silver SWISSTO12 SA (CH) 2026-02-03 US claimed
EP-4684002-A2 THYROCYTES AND USES THEREOF Lifenet Health (US) 2026-01-28 EP claimed
US-20260014282-A1 METHODS OF FORMING RADIOPAQUE PEPTIDES FOR USE IN MEDICAL HYDROGELS BOSTON SCIENTIFIC SCIMED, INC. (US) 2026-01-15 US claimed
US-12480021-B2 Composition for semiconductor process, method for preparing the same and method for preparing semiconductor device using the same SK ENPULSE CO., LTD. (KR) 2025-11-25 US claimed
US-12428447-B2 Peptide-based non-proteinaceous cargo delivery FELDAN BIO INC. (CA) 2025-09-30 US claimed
EP-4619043-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED COMPOUNDS AND USE THEREOF Perspective Therapeutics, Inc. (US) 2025-09-24 EP claimed
WO-2025128149-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED COMPOUNDS AND USE THEREOF VIEWPOINT MOLECULAR TARGETING, INC. (US) 2025-06-19 WO claimed
EP-0378318-A1 Process for synthesis of FK-506 and tricarbonyl intermediates MERCK & CO. INC. (US) 1990-07-18 EP claimed
US-4801742-A N-formylation of amino carboxylates with alkyl formates W. R. GRACE & CO.-CONN. (US) 1989-01-31 US claimed
US-4614770-A HYDROCYANATION OF CARBONYL, THIOCARBONYL OR IMINO GROUPS; POLYMERS BEARING PYRIDINE-NUCLEUS RING SUBSTITUTED BY CARBOXAMIDE GROUPS ALLIED CORPORATION (US) 1986-09-30 US claimed
US-4614769-A NADH2 mimics as chiral pseudohydrogenases ALLIED CORPORATION (US) 1986-09-30 US claimed
US-4524223-A CHROMATOGRAPHIC SEPARATION OF DIASTEREOMERIC ESTERS UOP INC. (US) 1985-06-18 US claimed
US-4453007-A FORMING CATIONIC SALT AND ANIONIC SALT WITH SEPARATE PORTIONS OF COMPOUND, MIXING, AND COLLECTING PRECIPITATE USV PHARMACEUTICAL CORPORATION (US) 1984-06-05 US claimed
US-4418225-A ESTERIFICATION WITH AMINO ACIDS UOP INC. (US) 1983-11-29 US claimed
EP-0046270-A1 Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them INTERx RESEARCH CORPORATION (US) 1982-02-24 EP claimed
US-4242256-A Synthesis of peptide analogues SHARPE ROBERT (GB) 1980-12-30 US claimed
US-3930948-A ENZYMATIC METHOD FOR PRODUCING AROMATIC ETHYLAMINES AJINOMOTO CO., INC. (JA) 1976-01-06 US claimed