Diotyrosine

Diotyrosine

SCHEMBL838215

N[C@H](Cc1cc(I)c(O)c(I)c1)C(=O)O

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT5 Q9NXA8 1/20 0.82
THRB P10828 8/20 0.75
THRA P10827 6/20 0.75
MEN1 O00255 5/20 0.75
KMT2A Q03164 5/20 0.75
LMNA P02545 4/20 0.75
PPARG P37231 4/20 0.75
TTR P02766 2/20 0.75
ADORA3 P0DMS8 2/20 0.75
PDE4D Q08499 2/20 0.75
HSD17B10 Q99714 2/20 0.75
NR1I2 O75469 2/20 0.75
NR3C1 P04150 1/20 0.75
CYP1A2 P05177 1/20 0.75
HTR1A P08908 1/20 0.75
CYP2C9 P11712 1/20 0.75
TBXA2R P21731 1/20 0.75
NTSR1 P30989 1/20 0.75
HTR2B P41595 1/20 0.75
USP2 O75604 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diotyrosine SCHEMBL147579 1.00 SIRT5 (0.82) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL147578 1.00 SIRT5 (0.82) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL31135680 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL14484740 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL5801627 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL1741366 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL31135662 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL28737936 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL16416106 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A
Diotyrosine SCHEMBL28737934 0.98 SIRT5 (0.79) SIRT5THRBTHRAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118914574-A Free triiodothyronine magnetic particle chemiluminescence detection kit and preparation method thereof 郑州达诺生物技术有限公司 2024-11-08 CN claimed
EP-1487493-B1 CONJUGATES OF CYTOTOXIC AGENTS AND BIOLOGICALLY ACTIVE PEPTIDES UNIV TULANE (US) 2010-01-20 EP claimed
EP-1131343-A4 HYDROPHILIC SOMATOSTATIN ANALOGS ADMINISTRATORS OFTHE TULANE UN (US) 2005-02-02 EP claimed
US-6465613-B1 ADMINISTERING A SOMATOSTATIN DERIVATIVE TO A PATIENT FOR SELECTIVELY TARGETING AND ARRESTING THE GROWTH OF AN ANGIOGENIC BLOOD VESSEL OR A CELL TULANE UNIVERSITY 2002-10-15 US claimed
EP-1131343-A1 HYDROPHILIC SOMATOSTATIN ANALOGS THE ADMINISTRATORS OF THE TULANE UNIVERSITY EDUCATIONAL FUND (US) 2001-09-12 EP claimed
WO-2000031122-A1 HYDROPHILIC SOMATOSTATIN ANALOGS TULANE UNIVERSITY (US) 2000-06-02 WO claimed
EP-4673162-A1 PATHOGEN-SPECIFIC PEPTIDE TO BLOCK VIRULENCE-RELATED SIGNALING IN CANDIDA ALBICANS I3S - Instituto de Investigação e Inovação em Saúde, Associação (PT) 2026-01-07 EP disclosed
US-20250367300-A1 Nanomaterial and Methods of Use Thereof UNIVERSITY OF CONNECTICUT (US) 2025-12-04 US disclosed
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF UNIVERSITY OF CONNECTICUT (US) 2025-10-02 US disclosed
US-20250302971-A1 Therapeutic Nanomaterials UNIV CONNECTICUT (US) 2025-10-02 US disclosed
US-20250229081-A1 NANOMATERIAL COATED ELECTRODE AND METHODS OF USE THEREOF UNIVERSITY OF CONNECTICUT 2025-07-17 US disclosed
EP-4578868-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR FUJIFILM Corporation (JP) 2025-07-02 EP disclosed
EP-4578867-A1 CYCLIC PEPTIDE OR SALT THEREOF AND MDMX INHIBITOR FUJIFILM Corporation (JP) 2025-07-02 EP disclosed
WO-2001066147-A2 ANTIMICROBIAL COMPOUNDS AND FORMULATIONS ALPHARMA AS (NO) 2001-09-13 WO disclosed
EP-1131343-A1 HYDROPHILIC SOMATOSTATIN ANALOGS THE ADMINISTRATORS OF THE TULANE UNIVERSITY EDUCATIONAL FUND (US) 2001-09-12 EP disclosed
EP-1109831-A2 CYCTOTOXIC PEPTIDES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES ALPHARMA AS (NO) 2001-06-27 EP disclosed
EP-1109827-A2 BIOACTIVE PEPTIDES ALPHARMA AS (NO) 2001-06-27 EP disclosed
WO-2000031122-A1 HYDROPHILIC SOMATOSTATIN ANALOGS TULANE UNIVERSITY (US) 2000-06-02 WO disclosed
WO-2000012542-A2 CYTOTOXIC LACTOFERRIN DERIVATIVES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES ALPHARMA AS (NO) 2000-03-09 WO disclosed
WO-2000012541-A2 CYTOTOXIC PEPTIDES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES ALPHARMA AS (NO) 2000-03-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302971-A1 Therapeutic Nanomaterials TIE1, TEKT1, POLRMT SIRT5 4840/4885THRB 2002/4885THRA 1549/4885
US-20250367300-A1 Nanomaterial and Methods of Use Thereof EPCAM, CD47, JAK2 SIRT5 3400/4885THRB 3982/4885THRA 3752/4885
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF JAK2, JAK1, CHMP4B SIRT5 4389/4885THRB 3115/4885THRA 2980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.