Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.77 |
| ▸ | GAA | P10253 | 4/20 | 0.77 |
| ▸ | HTT | P42858 | 4/20 | 0.77 |
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.77 |
| ▸ | CASP1 | P29466 | 2/20 | 0.77 |
| ▸ | CASP7 | P55210 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.77 |
| ▸ | HBB | P68871 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326101 | 0.87 | KMT2A (1.00) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL4331607 | 0.87 | MEN1 (0.79) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL6422466 | 0.83 | MEN1 (0.63) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL14478993 | 0.82 | GRK6 (0.69) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL82135 | 0.82 | MEN1 (0.52) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL16217134 | 0.80 | MEN1 (0.72) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL4335448 | 0.80 | MEN1 (0.76) | MEN1KMT2ANPSR1GAANPC1 | |
| SCHEMBL4331766 | 0.80 | MEN1 (0.83) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL6422443 | 0.79 | MEN1 (0.61) | MEN1KMT2ANPSR1GAAHTT | |
| SCHEMBL30628026 | 0.78 | KMT2A (1.00) | MEN1KMT2ANPSR1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047278-A1 | E3 UBIQUITIN LIGASE AGONISTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE E3 UBIQUITIN LIGASE AGONISTS, RELATED METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-02-18 | — | — | US | disclosed |
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-06 | — | — | US | disclosed |
| WO-2013033037-A2 | NOVEL ANTIPRION COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047278-A1 | E3 UBIQUITIN LIGASE AGONISTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE E3 UBIQUITIN LIGASE AGONISTS, RELATED METHODS OF USE | UBE3A, NEDD4, ADRM1 | MEN1 3691/4885KMT2A 2646/4885NPSR1 754/4885 |
| US-20140329863-A1 | NOVEL ANTIPRION COMPOUNDS | PRNP, PSEN1, PSEN2 | MEN1 4510/4885KMT2A 4582/4885NPSR1 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.