SCHEMBL14760290

SCHEMBL14760290

C[Si](Cl)(C(=O)Cc1ccccn1)C(=O)Cc1ccccn1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.53
NPC1 O15118 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.47
ALDH1A1 P00352 4/20 0.46
CYP1A2 P05177 1/20 0.46
TSHR P16473 1/20 0.46
PTPRA P18433 1/20 0.45
POLB P06746 2/20 0.44
IDO1 P14902 1/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HPGD P15428 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14760273 0.85 RAB9A (0.51) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL14759965 0.85 RAB9A (0.56) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL15662922 0.78 RAB9A (0.49) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL904686 0.77 RAB9A (0.59) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL29828134 0.77 ALDH1A1 (0.61) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL31324457 0.77 RAB9A (0.59) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL211090 0.77 ALDH1A1 (0.61) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL2142240 0.77 RAB9A (0.58) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
Hydrochloric Acid SCHEMBL3595586 0.76 RAB9A (0.57) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2
Hydrochloric Acid SCHEMBL31201564 0.76 RAB9A (0.57) RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130072647-A1 OLEFIN POLYMERIZATION CATALYST AND PREPARATION METHOD AND USE THEREOF PETROCHINA COMPANY LIMITED (CN) 2013-03-21 US claimed
EP-2567986-A1 OLEFIN POLYMERIZATION CATALYST AND PREPARATION METHOD AND USE THEREOF Petrochina Company Limited (CN) 2013-03-13 EP claimed
US-20130072647-A1 OLEFIN POLYMERIZATION CATALYST AND PREPARATION METHOD AND USE THEREOF PETROCHINA COMPANY LIMITED (CN) 2013-03-21 US disclosed
EP-2567986-A1 OLEFIN POLYMERIZATION CATALYST AND PREPARATION METHOD AND USE THEREOF Petrochina Company Limited (CN) 2013-03-13 EP disclosed