Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903304 | 0.86 | LMNA (0.69) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL5916445 | 0.86 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL5916487 | 0.82 | GAA (0.54) | SMN1; SMN2MAPTHPGDMEN1KMT2A | |
| SCHEMBL3074677 | 0.81 | KDM4E (0.71) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL5232948 | 0.77 | MGLL (0.60) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL4326148 | 0.76 | LMNA (0.64) | LMNASMN1; SMN2HTTMAPTMEN1 | |
| SCHEMBL18711414 | 0.75 | SMN1; SMN2 (0.70) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL29988025 | 0.74 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL27077767 | 0.74 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2HTTMAPTHPGD | |
| SCHEMBL4424697 | 0.74 | LMNA (0.68) | LMNASMN1; SMN2HTTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558578-B1 | NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-03-13 | — | — | EP | claimed |
| EP-1558578-B1 | NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-03-13 | — | — | EP | disclosed |