Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663037 | 0.80 | MEN1 (0.45) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL1392926 | 0.80 | MEN1 (0.38) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL28364565 | 0.79 | MEN1 (0.44) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL17209880 | 0.76 | MEN1 (0.39) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL1703714 | 0.75 | MEN1 (0.41) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL17187761 | 0.74 | MAPT (0.39) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL14764041 | 0.74 | MEN1 (0.43) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL10256261 | 0.74 | — | — | |
| SCHEMBL23776848 | 0.73 | MEN1 (0.38) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL31319648 | 0.73 | MAPT (0.40) | MEN1KMT2AMAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969335-B2 | Benzonitrile derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| US-20140228340-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| WO-2013034238-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228340-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | TBK1, NFKBIA, IKBKG | MEN1 3627/4885KMT2A 1285/4885MAPT 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.