SCHEMBL14764339

SCHEMBL14764339

COc1cc(-c2oc3cccc(O)c3c(=O)c2O)ccc1O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.76
KMT2A Q03164 5/20 0.76
CYP1A1 P04798 3/20 0.76
CYP1A2 P05177 3/20 0.76
CYP1B1 Q16678 3/20 0.76
XDH P47989 2/20 0.76
IPMK Q8NFU5 2/20 0.76
IP6K2 Q9UHH9 2/20 0.76
CA12 O43570 1/20 0.76
CA2 P00918 1/20 0.76
CA4 P22748 1/20 0.76
PPARG P37231 1/20 0.76
CA7 P43166 1/20 0.76
KDM4E B2RXH2 5/20 0.65
LMNA P02545 5/20 0.65
CYP3A4 P08684 5/20 0.65
MAPT P10636 5/20 0.65
HSD17B10 Q99714 4/20 0.65
TP53 P04637 4/20 0.65
HPGD P15428 3/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14764381 0.90 CYP1A1 (0.76) MEN1KMT2ACYP1A1CYP1A2CYP1B1
Isorhamnetin SCHEMBL19235 0.86 MEN1 (1.00) MEN1KMT2ACYP1A1CYP1A2CYP1B1
Isorhamnetin SCHEMBL29377152 0.86 MEN1 (1.00) MEN1KMT2ACYP1A1CYP1A2CYP1B1
Isorhamnetin SCHEMBL29390102 0.86 MEN1 (1.00) MEN1KMT2ACYP1A1CYP1A2CYP1B1
Isorhamnetin SCHEMBL30385934 0.86 MEN1 (1.00) MEN1KMT2ACYP1A1CYP1A2CYP1B1
Rhamnazin SCHEMBL39443 0.85 MEN1 (0.84) MEN1KMT2ACYP1A1CYP1A2CYP1B1
Rhamnazin SCHEMBL29724889 0.85 MEN1 (0.84) MEN1KMT2ACYP1A1CYP1A2CYP1B1
SCHEMBL7660030 0.85 NOX4 (0.76) MEN1KMT2ACYP1A1CYP1A2CYP1B1
SCHEMBL15844041 0.85 KDM4E (0.83) MEN1KMT2ACYP1A1CYP1A2CYP1B1
SCHEMBL18676308 0.84 MEN1 (0.72) MEN1KMT2ACYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013034119-A1 4-METHYLCATECHOL DERIVATIVES UND USE THEREOF Thanares GmbH (DE) 2013-03-14 WO disclosed