Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3132216 | 0.86 | PTGS2 (0.56) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL2550023 | 0.83 | MAPT (0.72) | MAPTSIRT6ALDH1A1POLBLMNA | |
| SCHEMBL28665095 | 0.81 | CA12 (0.62) | MAPTSIRT6ENPP2ALDH1A1LMNA | |
| SCHEMBL28679485 | 0.81 | CA12 (0.59) | MAPTSIRT6ENPP2POLB | |
| SCHEMBL6151230 | 0.79 | SIRT6 (0.81) | MAPTSIRT6ALDH1A1POLBLMNA | |
| SCHEMBL15271381 | 0.79 | SIRT6 (0.81) | MAPTSIRT6ALDH1A1POLBLMNA | |
| SCHEMBL14764658 | 0.77 | MAPT (0.53) | MAPTALDH1A1HTTPOLBLMNA | |
| SCHEMBL5743491 | 0.77 | SIRT6 (0.63) | MAPTSIRT6ALDH1A1POLBLMNA | |
| SCHEMBL8931734 | 0.76 | MEN1 (0.62) | MAPTSIRT6ALDH1A1POLBLMNA | |
| SCHEMBL11556563 | 0.76 | POLB (0.67) | MAPTALDH1A1HTTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545666-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-10 | — | — | US | disclosed |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-02-07 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| WO-2013036866-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885SIRT6 1603/4885ENPP2 1185/4885 |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885SIRT6 1603/4885ENPP2 1185/4885 |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885SIRT6 1603/4885ENPP2 1185/4885 |
| US-12545666-B2 | Itraconazole analogs and use thereof | SHH, SMO, GLI1 | MAPT 2130/4885SIRT6 2882/4885ENPP2 2958/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | MAPT 3556/4885SIRT6 1603/4885ENPP2 1185/4885 |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | SHH, GLI1, KDR | MAPT 3556/4885SIRT6 1603/4885ENPP2 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.