Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.78 |
| ▸ | PPARA | Q07869 | 3/20 | 0.71 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.63 |
| ▸ | LSS | P48449 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15525081 | 1.00 | GAA (0.78) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL5396195 | 0.93 | GAA (0.83) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL29102525 | 0.93 | GAA (0.66) | GAAPPARAHRH4LSSL3MBTL1 | |
| SCHEMBL2127341 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL20624042 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL6652325 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL2127003 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL14689477 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL7114335 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA | |
| SCHEMBL279013 | 0.93 | PPARA (0.81) | GAAPPARAHRH4LSSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545666-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-10 | — | — | US | disclosed |
| CN-111050730-B | Photoinitiator-modified polyacid polymers | 登特斯普伊德特雷有限公司 | 2023-07-28 | — | — | CN | disclosed |
| US-11628125-B2 | Photoinitiator modified polyacidic polymer | DENTSPLY SIRONA INC. (US) | 2023-04-18 | — | — | US | disclosed |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
| EP-3675800-B1 | PHOTOINITIATOR MODIFIED POLYACIDIC POLYMER | DENTSPLY DETREY GMBH (DE) | 2021-09-22 | — | — | EP | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20210069070-A1 | PHOTOINITIATOR MODIFIED POLYACIDIC POLYMER | DENTSPLY SIRONA INC. (US) | 2021-03-11 | — | — | US | disclosed |
| EP-3675800-A1 | PHOTOINITIATOR MODIFIED POLYACIDIC POLYMER | Dentsply DeTrey GmbH (DE) | 2020-07-08 | — | — | EP | disclosed |
| CN-111050730-A | Photoinitiator modified polyacid polymers | 登特斯普伊德特雷有限公司 | 2020-04-21 | — | — | CN | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| WO-2013036866-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210069070-A1 | PHOTOINITIATOR MODIFIED POLYACIDIC POLYMER | DOHH, OGDH, GGH | GAA 1624/4885PPARA 1149/4885HRH4 114/4885 |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | GAA 1408/4885PPARA 2428/4885HRH4 1525/4885 |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | GAA 1408/4885PPARA 2428/4885HRH4 1525/4885 |
| US-12545666-B2 | Itraconazole analogs and use thereof | SHH, SMO, GLI1 | GAA 4299/4885PPARA 2642/4885HRH4 2911/4885 |
| US-11628125-B2 | Photoinitiator modified polyacidic polymer | DOHH, OGDH, GGH | GAA 1624/4885PPARA 1149/4885HRH4 114/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | GAA 1408/4885PPARA 2428/4885HRH4 1525/4885 |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | SHH, GLI1, KDR | GAA 1408/4885PPARA 2428/4885HRH4 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.