SCHEMBL14764992

SCHEMBL14764992

Cc1ccc2nc(C)c3nnc(-c4c(Cl)cccc4Cl)n3c2c1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 20/20 0.63
PDE10A Q9Y233 14/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14764693 0.86 PDE2A (0.76) PDE2APDE10A
SCHEMBL14765006 0.86 PDE2A (0.81) PDE2APDE10A
SCHEMBL14362016 0.80 PDE2A (0.73) PDE2APDE10A
SCHEMBL17356919 0.80 PDE2A (0.62) PDE2APDE10A
SCHEMBL14362100 0.78 PDE2A (0.71) PDE2APDE10A
SCHEMBL14361940 0.78 PDE2A (1.00) PDE2APDE10A
SCHEMBL14475075 0.77 PDE2A (0.69) PDE2APDE10A
SCHEMBL12502559 0.77 PDE2A (1.00) PDE2APDE10A
SCHEMBL14473922 0.76 PDE2A (0.62) PDE2APDE10A
SCHEMBL12502536 0.75 PDE2A (1.00) PDE2APDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013034755-A1 TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS H. LUNDBECK A/S (DK) 2013-03-14 WO claimed
WO-2013034755-A1 TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS H. LUNDBECK A/S (DK) 2013-03-14 WO disclosed
WO-2013034755-A1 TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS H. LUNDBECK A/S (DK) 2013-03-14 WO disclosed