Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 19/20 | 0.81 |
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.68 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764693 | 0.90 | PDE2A (0.76) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL12502536 | 0.90 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL14764901 | 0.90 | PDE2A (0.78) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL12503036 | 0.88 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11A | |
| SCHEMBL14361813 | 0.88 | PDE2A (0.82) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL12502680 | 0.88 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL14362126 | 0.88 | PDE2A (0.78) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL12502893 | 0.87 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11A | |
| SCHEMBL14764992 | 0.86 | PDE2A (0.63) | PDE2APDE10A | |
| SCHEMBL14361873 | 0.85 | PDE2A (0.83) | PDE2APDE10APDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |