Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736859 | 0.83 | PDE10A (0.47) | PDE10ALMNANR1H3ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL14736798 | 0.82 | PDE10A (0.46) | PDE10ALMNANR1H3ALDH1A1GAA | |
| SCHEMBL14736857 | 0.80 | PDE10A (0.47) | PDE10ALMNAALDH1A1GAARAB9A | |
| SCHEMBL14736479 | 0.77 | PDE10A (0.61) | PDE10ALMNANR1H3ALDH1A1GAA | |
| SCHEMBL1272731 | 0.65 | PDE10A (0.41) | PDE10ALMNANR1H3ALDH1A1GAA | |
| SCHEMBL14736525 | 0.65 | PDE10A (0.45) | PDE10ALMNANR1H3ALDH1A1GAA | |
| SCHEMBL15653455 | 0.65 | RAB9A (0.36) | LMNAALDH1A1GAARAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL14736548 | 0.64 | PDE10A (0.45) | PDE10ALMNANR1H3ALDH1A1GAA | |
| SCHEMBL23566114 | 0.64 | CRHR1 (0.58) | PDE10ALMNAALDH1A1RAB9AMEN1 | |
| SCHEMBL3023672 | 0.64 | CRHR1 (0.43) | LMNAALDH1A1GAARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |