Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798155 | 0.79 | PHGDH (0.60) | PKMPHGDHHPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL20260141 | 0.72 | HPGD (0.58) | PKMPHGDHHPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL31703280 | 0.68 | PKM (0.49) | PKMPHGDHHPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL30314408 | 0.67 | HSD11B1 (0.62) | HPGDALDH1A1NPC1TSHRKDM4E | |
| SCHEMBL3993564 | 0.67 | PHGDH (0.63) | PKMPHGDHHPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL31118747 | 0.66 | LRRK2 (0.45) | PKMPHGDHHPGDAKR1C3LRRK2 | |
| SCHEMBL6578719 | 0.65 | POLB (0.60) | HPGDMAPTALDH1A1LMNATSHR | |
| SCHEMBL3249195 | 0.64 | PKM (0.63) | PKMPHGDHHPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL22353354 | 0.62 | HPGD (0.56) | PKMPHGDHHPGDSMN1; SMN2MAPT | |
| SCHEMBL26604114 | 0.62 | HPGD (0.55) | PKMPHGDHHPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394792-B2 | Heterocyclic derivatives | C&C RESEARCH LABORATORIES (KR) | 2013-03-12 | — | — | US | disclosed |
| US-8394792-B2 | Heterocyclic derivatives | C&C RESEARCH LABORATORIES (KR) | 2013-03-12 | — | — | US | disclosed |