Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765465 | 0.96 | EPHA2 (0.42) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL13484562 | 0.85 | KDM4E (0.57) | SMN1; SMN2ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL14765488 | 0.82 | L3MBTL1 (0.45) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL14765483 | 0.81 | L3MBTL1 (0.45) | RAB9ANPC1ALDH1A1MAPTNPSR1 | |
| SCHEMBL13484563 | 0.81 | KDM4E (0.52) | SMN1; SMN2ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL14765475 | 0.76 | L3MBTL1 (0.55) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL14765476 | 0.75 | CYP1A2 (0.50) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL14765480 | 0.72 | L3MBTL1 (0.53) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL14765485 | 0.71 | BCHE (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL14765481 | 0.71 | MAPT (0.47) | RAB9ANPC1ALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394841-B2 | Compounds and methods for modulating G protein-coupled receptors | IRM LLC (BM) | 2013-03-12 | — | — | US | disclosed |