Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 12/20 | 0.58 |
| ▸ | MME | P08473 | 10/20 | 0.52 |
| ▸ | ACE | P12821 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765548 | 0.90 | MME (0.48) | MMEL1MMEACE | |
| SCHEMBL10197772 | 0.86 | MMEL1 (0.78) | MMEL1MMEACE | |
| SCHEMBL12975548 | 0.86 | MMEL1 (0.59) | MMEL1MMEACE | |
| SCHEMBL14873509 | 0.84 | MMEL1 (0.63) | MMEL1MMEACE | |
| SCHEMBL16132549 | 0.83 | MMEL1 (0.61) | MMEL1MMEACE | |
| SCHEMBL8531372 | 0.83 | MMEL1 (0.64) | MMEL1MMEACE | |
| SCHEMBL10198457 | 0.83 | MMEL1 (0.66) | MMEL1MMEACE | |
| SCHEMBL12975552 | 0.82 | MMEL1 (0.61) | MMEL1MMEACE | |
| SCHEMBL8581319 | 0.81 | MMEL1 (0.59) | MMEL1MMEACE | |
| SCHEMBL8552535 | 0.80 | MMEL1 (0.67) | MMEL1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394853-B2 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2013-03-12 | — | — | US | disclosed |