Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 14/20 | 0.48 |
| ▸ | ACE | P12821 | 5/20 | 0.48 |
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.48 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765547 | 0.90 | MMEL1 (0.58) | MMEACEMMEL1 | |
| SCHEMBL12975218 | 0.86 | MMEL1 (0.61) | MMEACEMMEL1GPR34 | |
| SCHEMBL14765359 | 0.81 | MME (0.49) | MMEACEMMEL1GPR34 | |
| SCHEMBL14873441 | 0.80 | MME (0.50) | MMEACEMMEL1GPR34 | |
| SCHEMBL12974911 | 0.78 | MME (0.77) | MMEMMEL1 | |
| SCHEMBL14952898 | 0.78 | MME (0.77) | MMEMMEL1 | |
| SCHEMBL8531544 | 0.77 | MME (0.65) | MMEACEMMEL1 | |
| SCHEMBL12975711 | 0.77 | MME (0.52) | MMEACEMMEL1GPR34 | |
| SCHEMBL12975548 | 0.76 | MMEL1 (0.59) | MMEACEMMEL1 | |
| SCHEMBL10197772 | 0.76 | MMEL1 (0.78) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394853-B2 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2013-03-12 | — | — | US | disclosed |