SCHEMBL14766314

SCHEMBL14766314

CCOc1ccc(C2CCC(COc3ccc(-c4ccc(OC)cc4)c(F)c3F)CC2)c(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 3/20 0.37
ALOX5AP P20292 3/20 0.36
FEN1 P39748 3/20 0.36
TDP1 Q9NUW8 1/20 0.36
FFAR1 O14842 7/20 0.36
SYK P43405 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
PDE4A P27815 1/20 0.36
PDE4B Q07343 1/20 0.36
PDE4C Q08493 1/20 0.36
PDE4D Q08499 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12823874 1.00 FPR2 (0.37) FPR2ALOX5APFEN1TDP1FFAR1
SCHEMBL12821289 0.94 FPR2 (0.39) FPR2ALOX5APFEN1TDP1FFAR1
SCHEMBL12823006 0.94 FPR2 (0.39) FPR2ALOX5APFEN1TDP1FFAR1
SCHEMBL14766934 0.93 SSTR5 (0.38) FPR2ALOX5APFEN1FFAR1PDE4D
SCHEMBL14766305 0.93 SSTR5 (0.38) FPR2ALOX5APFEN1FFAR1PDE4D
SCHEMBL13586297 0.93 ALOX5AP (0.40) FPR2ALOX5APFEN1SYKADORA3
SCHEMBL13586395 0.91 FFAR1 (0.42) FPR2FFAR1
SCHEMBL13586430 0.91 FFAR1 (0.40) FPR2FFAR1
SCHEMBL12823282 0.90 FFAR1 (0.40) FFAR1SYKPDE4APDE4BPDE4C
SCHEMBL12822687 0.90 FPR2 (0.38) FPR2ALOX5APFEN1TDP1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8394294-B2 Four-ring liquid crystal compound having lateral fluorine, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-03-12 US disclosed