Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12441119 | 0.90 | MCHR1 (0.58) | MCHR1HTR2CHRH3 | |
| SCHEMBL12441100 | 0.86 | MCHR1 (0.69) | MCHR1LTA4HHRH3 | |
| SCHEMBL6957842 | 0.78 | MCHR1 (0.70) | MCHR1HTR2CLTA4H | |
| SCHEMBL12440363 | 0.78 | MCHR1 (0.57) | MCHR1HRH3 | |
| SCHEMBL14767433 | 0.78 | SMN1; SMN2 (0.51) | MCHR1HTR2CLTA4HHRH3 | |
| SCHEMBL12440267 | 0.77 | MCHR1 (0.67) | MCHR1LTA4H | |
| SCHEMBL14767429 | 0.77 | MCHR1 (0.46) | MCHR1LTA4HHRH3 | |
| SCHEMBL12439925 | 0.77 | SMN1; SMN2 (0.56) | MCHR1HTR2CHRH3 | |
| SCHEMBL12441464 | 0.77 | MCHR1 (0.53) | MCHR1HTR2CLTA4H | |
| SCHEMBL7443460 | 0.76 | LTA4H (0.77) | MCHR1LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558578-B1 | NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-03-13 | — | — | EP | disclosed |