Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12649067 | 1.00 | PDE3B (0.46) | PDE3BPDE3ANOTUMHRH3KDR | |
| SCHEMBL1769918 | 0.87 | PDE3B (0.59) | PDE3BPDE3ANOTUMHRH3KDR | |
| SCHEMBL12595842 | 0.85 | HRH3 (0.43) | PDE3BPDE3AHRH3 | |
| SCHEMBL12649105 | 0.85 | PDE3B (0.47) | PDE3BPDE3ANOTUMHRH3KDR | |
| SCHEMBL13071053 | 0.83 | ALDH1A1 (0.46) | PDE3BPDE3ANOTUMITGB2ICAM1 | |
| SCHEMBL13071051 | 0.83 | NOTUM (0.62) | PDE3BPDE3ANOTUMHRH3KDR | |
| SCHEMBL25698377 | 0.82 | NOTUM (0.47) | PDE3BPDE3ANOTUMHRH3KDR | |
| SCHEMBL13071049 | 0.82 | PDE3B (0.59) | PDE3BPDE3ANOTUMKDRITGB2 | |
| SCHEMBL1769904 | 0.82 | PDE3B (0.55) | PDE3BPDE3ANOTUM | |
| SCHEMBL1769796 | 0.82 | NOTUM (0.61) | PDE3BPDE3ANOTUMHRH3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253625-B1 | PYRIDAZINONES, THE PREPARATION AND THE USE THEREOF | SHANGHAI INST MATERIA MEDICA (CN) | 2013-03-13 | — | — | EP | disclosed |