Sugi Predict

Sugi Predict / Compounds / SCHEMBL14768591

SCHEMBL14768591

SCHEMBL14768591

Cc1cc(Cl)cc(Sc2ccc(C#N)cc2CN2CCC(C)CC2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 3/20 0.38
▸ DRD2 P14416 2/20 0.36
▸ DRD4 P21917 2/20 0.36
▸ DRD3 P35462 2/20 0.36
▸ HRH3 Q9Y5N1 3/20 0.36
▸ HRH2 P25021 1/20 0.36
▸ HRH1 P35367 1/20 0.36
▸ KDM1A O60341 1/20 0.36
▸ RAB9A P51151 4/20 0.35
▸ TSHR P16473 3/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ GPR6 P46095 2/20 0.35
▸ HTR1A P08908 1/20 0.34
▸ HTR3A P46098 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14768590 0.93 ACHE (0.41) ACHEDRD2DRD4DRD3HRH3
SCHEMBL14768585 0.92 KDM1A (0.38) DRD2DRD4DRD3HRH3KDM1A
SCHEMBL14768607 0.89 CHRNA7 (0.39) DRD2DRD4DRD3HRH3ALDH1A1
SCHEMBL14768595 0.88 MEN1 (0.35) ACHEDRD2DRD4DRD3HRH3
SCHEMBL14768623 0.87 CYP2A13 (0.40) DRD2DRD4DRD3HRH3RAB9A
SCHEMBL14768596 0.87 L3MBTL1 (0.38) DRD2DRD4DRD3ALDH1A1SMN1; SMN2
SCHEMBL14039266 0.85 MLNR (0.39) DRD2DRD4DRD3KDM1AHTR1A
SCHEMBL14768622 0.85 KMT2A (0.40) DRD2DRD4DRD3KDM1AALDH1A1
SCHEMBL14039315 0.85 DRD4 (0.34) DRD2DRD4DRD3HTR1AHTR3A
SCHEMBL14039313 0.81 SLC6A4 (0.40) DRD2DRD4DRD3HRH3KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 — — US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 — — US disclosed
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2014-03-06 — — US disclosed
US-8563544-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-10-22 — — US disclosed
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-03-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ACHE 4744/4885DRD2 1856/4885DRD4 2939/4885
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ACHE 4744/4885DRD2 1856/4885DRD4 2939/4885
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ACHE 4744/4885DRD2 1856/4885DRD4 2939/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.