Sugi Predict

Sugi Predict / Compounds / SCHEMBL14768628

SCHEMBL14768628

SCHEMBL14768628

Cc1cc(Sc2ccc(C#N)cc2CN2CCS(=O)(=O)CC2)cc(C(F)(F)F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.40
▸ KMT2A Q03164 2/20 0.39
▸ ALK Q9UM73 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ CYP2D6 P10635 3/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ USP2 O75604 2/20 0.35
▸ ELANE P08246 1/20 0.33
▸ TACR1 P25103 1/20 0.33
▸ CYP2C19 P33261 2/20 0.33
▸ DDR1 Q08345 4/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ GRM2 Q14416 1/20 0.32
▸ KDM1A O60341 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14768599 0.90 KMT2A (0.41) KMT2AALKMEN1SMN1; SMN2ALDH1A1
SCHEMBL14768626 0.87 ELANE (0.42) LMNAKMT2AMEN1CYP2D6SMN1; SMN2
SCHEMBL14768601 0.87 USP2 (0.34) CYP2D6SMN1; SMN2USP2ELANETACR1
SCHEMBL14768622 0.85 KMT2A (0.40) KMT2AALKMEN1ALDH1A1NPC1
SCHEMBL15334542 0.83 DDR1 (0.31) LMNAALKELANEDDR1
SCHEMBL14768619 0.77 CHRNA7 (0.43) LMNAKMT2AALDH1A1KDM1AL3MBTL1
SCHEMBL14768634 0.75 ADORA2A (0.35) KDM1A
SCHEMBL14768592 0.75 CYP2A13 (0.40) KMT2AMEN1KDM1ACYP2C9
SCHEMBL14768590 0.74 ACHE (0.41) KMT2AMEN1SMN1; SMN2ALDH1A1NPC1
SCHEMBL14768607 0.73 CHRNA7 (0.39) SMN1; SMN2ALDH1A1L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 — — US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 — — US disclosed
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2014-03-06 — — US disclosed
US-8563544-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-10-22 — — US disclosed
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-03-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 LMNA 4120/4885KMT2A 2893/4885ALK 3251/4885
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 LMNA 4120/4885KMT2A 2893/4885ALK 3251/4885
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 LMNA 4120/4885KMT2A 2893/4885ALK 3251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.