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SCHEMBL14768626

SCHEMBL14768626

Cc1cc(Sc2ccc(C#N)cc2CN2CCOCC2)cc(C(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 1/20 0.42
▸ SLC6A4 P31645 3/20 0.40
▸ HRH3 Q9Y5N1 3/20 0.40
▸ RORC P51449 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ LMNA P02545 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ PSMD14 O00487 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ MOK Q9UQ07 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ TSHR P16473 1/20 0.36
▸ MAPT P10636 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ ALOX5AP P20292 1/20 0.35
▸ FEN1 P39748 1/20 0.35
▸ SLC6A2 P23975 1/20 0.35
▸ SLC6A3 Q01959 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14768592 0.90 CYP2A13 (0.40) SLC6A4HRH3MEN1KMT2AMOK
SCHEMBL14768601 0.88 USP2 (0.34) ELANESLC6A4HRH3SMN1; SMN2SLC6A2
SCHEMBL14768628 0.87 LMNA (0.40) ELANEALDH1A1LMNAMEN1KMT2A
SCHEMBL14768623 0.85 CYP2A13 (0.40) SLC6A4HRH3LMNAMEN1KMT2A
SCHEMBL14768619 0.79 CHRNA7 (0.43) HRH3ALDH1A1LMNAKMT2ATSHR
SCHEMBL14768634 0.77 ADORA2A (0.35) SLC6A4HRH3CYP2A13
SCHEMBL14768585 0.76 KDM1A (0.38) SLC6A4HRH3ALDH1A1SLC6A2SLC6A3
SCHEMBL14768590 0.76 ACHE (0.41) HRH3ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL14768599 0.75 KMT2A (0.41) ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL14768607 0.74 CHRNA7 (0.39) HRH3ALDH1A1SMN1; SMN2MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 — — US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 — — US disclosed
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2014-03-06 — — US disclosed
US-8563544-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-10-22 — — US disclosed
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-03-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ELANE 503/4885SLC6A4 1650/4885HRH3 142/4885
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ELANE 503/4885SLC6A4 1650/4885HRH3 142/4885
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 ELANE 503/4885SLC6A4 1650/4885HRH3 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.