Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 11/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497506 | 0.81 | CARM1 (0.44) | SMN1; SMN2THRBTOP2ATOP2BVCP | |
| SCHEMBL12348825 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2THRBTOP2ATOP2BALDH1A1 | |
| SCHEMBL21843818 | 0.77 | TOP2A (0.41) | SMN1; SMN2THRBTOP2ATOP2BVCP | |
| SCHEMBL12403782 | 0.77 | HSD17B10 (0.48) | SMN1; SMN2CACNA1HALDH1A1POLB | |
| SCHEMBL13600600 | 0.77 | THRB (0.39) | SMN1; SMN2THRBTOP2ATOP2B | |
| SCHEMBL18850988 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2THRBRAB9A | |
| SCHEMBL13238482 | 0.76 | DRD2 (0.47) | THRBCACNA1HALDH1A1 | |
| SCHEMBL257071 | 0.75 | THRB (0.45) | SMN1; SMN2THRBTOP2ATOP2BALDH1A1 | |
| SCHEMBL4480059 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2THRBTOP2ATOP2BVCP | |
| SCHEMBL4480055 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2THRBTOP2ATOP2BVCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065883-A1 | Triazolo [4, 5- B] Pyridin Derivatives | Centro Nacional de Investigaceiones Oncologicas (CNIO) (ES) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065883-A1 | Triazolo [4, 5- B] Pyridin Derivatives | PIM1, PIM3, PIM2 | SMN1; SMN2 4123/4885THRB 401/4885TOP2A 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.