Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.57 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15807369 | 0.85 | NPC1 (0.56) | TNFRSF1AABCG2ABCB1MAPTMAOB | |
| SCHEMBL15807343 | 0.84 | TNFRSF1A (0.79) | TNFRSF1AABCG2ABCB1MAPTMAOB | |
| SCHEMBL12484514 | 0.84 | TNFRSF1A (1.00) | TNFRSF1AABCG2ABCB1 | |
| SCHEMBL12484518 | 0.84 | TNFRSF1A (1.00) | TNFRSF1AABCG2ABCB1 | |
| SCHEMBL15807324 | 0.83 | ABCG2 (0.58) | TNFRSF1AABCG2MAPTMAOBMEN1 | |
| SCHEMBL15807321 | 0.83 | CXCL12 (0.62) | TNFRSF1AABCG2ABCB1MAOBCYP1B1 | |
| SCHEMBL15807368 | 0.83 | MAOB (0.66) | TNFRSF1AABCG2ABCB1MAOB | |
| SCHEMBL15807327 | 0.83 | P4HB (0.71) | TNFRSF1AABCG2ABCB1MAOB | |
| SCHEMBL15460412 | 0.83 | TUBB1 (0.74) | ABCG2MAPTMEN1KMT2ACYP1B1 | |
| SCHEMBL15807322 | 0.82 | KRAS (0.76) | ABCG2MAPTMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889874-B2 | Imidazolone-chalcone derivatives as potential anticancer agent and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-11-18 | — | — | US | disclosed |
| US-20140171503-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | HUMAN SERVICES (US) | 2014-06-19 | — | — | US | disclosed |
| US-20130066081-A1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130066081-A1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | SIK1, SIK2, SIK3 | TNFRSF1A 2778/4885ABCG2 390/4885ABCB1 571/4885 |
| US-20140171503-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | AR, NCOA1, NR5A1 | TNFRSF1A 777/4885ABCG2 742/4885ABCB1 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.