SCHEMBL14770381

SCHEMBL14770381

CCc1nc2cc(Cl)ccn2c1C(=O)NCc1ccc(Oc2ccc(C)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 7/20 0.66
CYP2C19 P33261 5/20 0.60
CYP3A4 P08684 5/20 0.57
HTT P42858 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
KDM4E B2RXH2 2/20 0.46
PKM P14618 2/20 0.46
LMNA P02545 1/20 0.46
CHRNA7 P36544 1/20 0.46
MAPK14 Q16539 3/20 0.45
MMP13 P45452 2/20 0.44
MMP2 P08253 1/20 0.44
STAT3 P40763 1/20 0.44
HPGD P15428 2/20 0.41
ALDH1A1 P00352 1/20 0.41
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12295435 0.94 CYP2C9 (0.68) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL17590032 0.92 CYP2C9 (0.63) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL2402348 0.91 CYP2C9 (0.68) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL12294629 0.91 CYP2C9 (0.63) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL14761082 0.89 CYP2C9 (0.83) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL12295420 0.88 CYP2C9 (0.73) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL16447601 0.87 CYP2C9 (0.77) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL12296317 0.86 CYP2C9 (0.66) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL13837938 0.86 CYP2C9 (0.66) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2
SCHEMBL12295656 0.86 CYP2C9 (0.87) CYP2C9CYP2C19CYP3A4HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130065884-A1 Anti-Infective Compounds INSTITUT PASTEUR KOREA (KR) 2013-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130065884-A1 Anti-Infective Compounds RABGGTB, ELANE, SERPINB1 CYP2C9 4235/4885CYP2C19 4181/4885CYP3A4 2915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.