Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 8/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 7/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 7/20 | 1.00 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.91 |
| ▸ | OSBP | P22059 | 4/20 | 0.91 |
| ▸ | RORC | P51449 | 4/20 | 0.91 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.91 |
| ▸ | CRYAB | P02511 | 1/20 | 0.91 |
| ▸ | HMGCR | P04035 | 1/20 | 0.91 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.91 |
| ▸ | ITGAV | P06756 | 1/20 | 0.91 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.91 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.91 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.78 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.75 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.75 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.74 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14771158 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL16139847 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL16139954 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL25703762 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL19506256 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL16786297 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL19506552 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL25035613 | 0.95 | OSBP (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL12224955 | 0.95 | OSBP (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP | |
| SCHEMBL22559541 | 0.95 | OSBP (1.00) | GRIN1GRIN2AGRIN2BNR1H3OSBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4245369-A2 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | Sage Therapeutics, Inc. (US) | 2023-09-20 | — | — | EP | disclosed |
| US-20230192756-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | Sage Therapeutics, LLC | 2023-06-22 | — | — | US | disclosed |
| EP-2753632-B1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS INC (US) | 2023-05-10 | — | — | EP | disclosed |
| EP-3932932-A1 | NEUROACTIVE STERIODS AND METHODS OF USE THEREOF | Sage Therapeutics, Inc. (US) | 2022-01-05 | — | — | EP | disclosed |
| EP-3865135-A2 | NEUROACTIVE STEROIDS FOR USE IN THERAPY | Sage Therapeutics, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20210147470-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2021-05-20 | — | — | US | disclosed |
| EP-3461834-B1 | NEUROACTIVE STEROIDS | SAGE THERAPEUTICS INC (US) | 2021-05-19 | — | — | EP | disclosed |
| US-10759828-B2 | Neuroactive steroids, compositions, and uses thereof | SAGE THERAPEUTICS, INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20190127414-A1 | NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2019-05-02 | — | — | US | disclosed |
| EP-3461834-A1 | NEUROACTIVE STEROIDS | Sage Therapeutics, Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| US-10227375-B2 | Neuroactive steroids and methods of use thereof | SAGE THERAPEUTICS, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20170305960-A1 | NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2017-10-26 | — | — | US | disclosed |
| US-20160031930-A1 | NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160022701-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS INC (US) | 2016-01-28 | — | — | US | disclosed |
| US-20150158903-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. (US) | 2015-06-11 | — | — | US | disclosed |
| WO-2014160441-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2013036835-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. (US) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127414-A1 | NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | AVPR1B, MC2R, NPSR1 | GRIN1 121/4885GRIN2A 32/4885GRIN2B 16/4885 |
| US-20210147470-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CHRNB4, CHRNB3, MC2R | GRIN1 196/4885GRIN2A 90/4885GRIN2B 52/4885 |
| US-20160022701-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CYP21A2, CYP24A1, HSD17B2 | GRIN1 518/4885GRIN2A 155/4885GRIN2B 169/4885 |
| US-20160031930-A1 | NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | CYP21A2, CYP17A1, HSD17B7 | GRIN1 96/4885GRIN2A 49/4885GRIN2B 26/4885 |
| US-10759828-B2 | Neuroactive steroids, compositions, and uses thereof | CHRNB4, CHRNB3, MC2R | GRIN1 196/4885GRIN2A 90/4885GRIN2B 52/4885 |
| US-20170305960-A1 | NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | AVPR1B, MC2R, NPSR1 | GRIN1 121/4885GRIN2A 32/4885GRIN2B 16/4885 |
| US-20230192756-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CHRNB4, CHRNB3, MC2R | GRIN1 199/4885GRIN2A 96/4885GRIN2B 50/4885 |
| US-10227375-B2 | Neuroactive steroids and methods of use thereof | AVPR1B, MC2R, NPSR1 | GRIN1 121/4885GRIN2A 32/4885GRIN2B 16/4885 |
| US-20150158903-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CHRNB4, CHRNB3, MC2R | GRIN1 199/4885GRIN2A 96/4885GRIN2B 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.