SCHEMBL1477136

SCHEMBL1477136

O=C(O)c1ccc2c(Cl)cc(C(=O)O)cc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.61
TTR P02766 5/20 0.52
PTPN1 P18031 1/20 0.50
SRD5A2 P31213 1/20 0.48
MAPT P10636 2/20 0.46
ALDH1A1 P00352 1/20 0.46
ALOX15 P16050 1/20 0.45
TPMT P51580 1/20 0.45
KDM4E B2RXH2 2/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
TP53 P04637 1/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
POLB P06746 1/20 0.42
GAA P10253 1/20 0.42
CA4 P22748 1/20 0.42
CA6 P23280 1/20 0.42
PTGS2 P35354 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30390332 0.89 TTR (0.48) TSHRTTRSRD5A2ALDH1A1ALOX15
SCHEMBL12004297 0.89 TSHR (0.52) TSHRTTRPTPN1SRD5A2MAPT
SCHEMBL9516005 0.86 TSHR (0.59) TSHRTTRPTPN1SRD5A2MAPT
SCHEMBL7840769 0.82 MEN1 (0.52) TSHRTTRPTPN1SRD5A2MAPT
SCHEMBL5664701 0.81 PTPN1 (0.66) TSHRTTRPTPN1MAPTALDH1A1
SCHEMBL6914950 0.79 PTPN1 (0.64) TSHRTTRPTPN1MAPTALDH1A1
SCHEMBL6914903 0.79 PTPN1 (0.64) TSHRTTRPTPN1MAPTALDH1A1
SCHEMBL6915287 0.79 PTPN1 (0.64) TSHRTTRPTPN1MAPTALDH1A1
SCHEMBL6915348 0.79 PTPN1 (0.64) TSHRTTRPTPN1MAPTALDH1A1
SCHEMBL6916903 0.79 PTPN1 (0.64) TSHRTTRPTPN1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5151458-A Molding materials for liquid crystal resins BAYER AKTIENGESELLSCHAFT (DE) 1992-09-29 US claimed
US-5143956-A Blends with low molecular weight liquid crystals BAYER AKTIENGESELLSCHAFT (DE) 1992-09-01 US claimed
US-5102935-A With low molecular weight, liquid crystalline esters and/or ester amides BAYER AKTIENGESELLSCHAFT (DE) 1992-04-07 US claimed
EP-0464351-A2 Polycarbonate, polyestercarbonate and polyester moulding compositions with high melt flow BAYER AG (DE) 1992-01-08 EP claimed
EP-0444295-A1 Low-viscosity polyamide mouldings BAYER AG (DE) 1991-09-04 EP claimed
EP-0444292-A2 Easy fluoring polyamide moulding compositions BAYER AG (DE) 1991-09-04 EP claimed
EP-0398052-A2 Low-viscosity polyarylene sulfide mouldings BAYER AG (DE) 1990-11-22 EP claimed
EP-0359037-A2 Low-viscosity polyamide mouldings and mixtures BAYER AG (DE) 1990-03-21 EP claimed
US-4042571-A Fire-retardant polyamides from naphthalene dicarboxylic reactant and halogenated carboxylic reactant TEIJIN LIMITED (JA) 1977-08-16 US claimed
US-8496616-B2 Medical device employing liquid crystal block copolymers and method of making the same BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-07-30 US disclosed
EP-1991286-B1 MEDICAL DEVICE EMPLOYING LIQUID CRYSTAL BLOCK COPOLYMERS AND METHOD OF MAKING THE SAME BOSTON SCIENT LTD (BB) 2012-12-26 EP disclosed
US-20120220932-A1 MEDICAL DEVICE EMPLOYING LIQUID CRYSTAL BLOCK COPOLYMERS AND METHOD OF MAKING THE SAME BOSTON SCIENTIFIC SCIMED, INC. (US) 2012-08-30 US disclosed
US-8187492-B2 Medical device employing liquid crystal block copolymers and method of making the same BOSTON SCIENTIFIC SCIMED, INC. (US) 2012-05-29 US disclosed
US-20110092999-A1 MEDICAL DEVICE EMPLOYING LIQUID CRYSTAL BLOCK COPOLYMERS AND METHOD OF MAKING THE SAME BOSTON SCIENTIFIC SCIMED, INC. (US) 2011-04-21 US disclosed
EP-0236837-A2 Mixtures of polycarbonate polysiloxane block cocondensates and thermotropic polymers, process for preparing them and their use in making mouldings, filaments, fibres and foils BAYER AG (DE) 1987-09-16 EP disclosed
US-4599395-A Thermotropic, aromatic polyesters having good mechanical strength, containing sulfonic acid groups or metal sulfonate groups a process for the production thereof BAYER AKTIENGESELLSCHAFT (DE) 1986-07-08 US disclosed
EP-0141320-A2 Thermotropic aromatic polyesters with high stiffness, process for their production and their use in the production of moulded articles, filaments, fibres and films BAYER AG (DE) 1985-05-15 EP disclosed
EP-0024499-B1 BIAXIALLY ORIENTED WHOLLY AROMATIC POLYESTER FILM AND PROCESS FOR PRODUCING SAME TEIJIN LIMITED (JP) 1984-03-07 EP disclosed
US-4333907-A Biaxially oriented wholly aromatic polyester film TEITIN LIMITED (JP) 1982-06-08 US disclosed
EP-0024499-A1 Biaxially oriented wholly aromatic polyester film and process for producing same TEIJIN LIMITED (JP) 1981-03-11 EP disclosed