SCHEMBL7840769

SCHEMBL7840769

O=C(O)c1cc(Cl)c2ccccc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
ALDH1A1 P00352 3/20 0.52
HPGD P15428 3/20 0.52
KDM4E B2RXH2 2/20 0.52
HSD17B10 Q99714 2/20 0.52
CYP1A2 P05177 2/20 0.52
GLA P06280 1/20 0.52
CYP2C19 P33261 1/20 0.52
TTR P02766 4/20 0.50
MAPT P10636 2/20 0.49
PTPN1 P18031 1/20 0.49
PKM P14618 1/20 0.49
HTT P42858 1/20 0.49
TSHR P16473 2/20 0.48
GRIN2D O15399 1/20 0.45
GRIN2A Q12879 1/20 0.45
GRIN2C Q14957 1/20 0.45
MGAM O43451 1/20 0.44
CTRC Q99895 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7840767 0.85 ALDH1A1 (0.44) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL11688186 0.83 KMT2A (0.46) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL1477136 0.82 TSHR (0.61) MEN1KMT2AALDH1A1KDM4ETTR
SCHEMBL9516005 0.81 TSHR (0.59) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL30363668 0.80 MEN1 (0.55) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL7554285 0.80 MEN1 (0.55) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL5664701 0.79 PTPN1 (0.66) MEN1KMT2AALDH1A1HPGDCYP1A2
SCHEMBL30390332 0.79 TTR (0.48) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL28217120 0.79 ALDH1A1 (0.49) MEN1KMT2AALDH1A1HPGDKDM4E
SCHEMBL70654 0.78 PTPN1 (0.65) MEN1KMT2AALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118637984-A Synthesis method of (4-chloro-naphthalene-2-yl) -methanol 埃法姆(常州)生命科学技术有限公司 2024-09-13 CN claimed
EP-0244167-B1 IMPROVED PROCESS FOR PREPARING POLY (ARYL ETHERS) AND POLY (ARYL ETHER KETONES) AMOCO CORPORATION (US) 1990-04-04 EP claimed
US-4748227-A Process for preparing poly(aryl ether)ketones using a sodium carbonate/organic acid salt catalyst AMOCO CORPORATION (US) 1988-05-31 US claimed
EP-0244167-A1 Improved process for preparing poly (aryl ethers) and poly (aryl ether ketones) AMOCO CORPORATION (US) 1987-11-04 EP claimed
CN-118637984-A Synthesis method of (4-chloro-naphthalene-2-yl) -methanol 埃法姆(常州)生命科学技术有限公司 2024-09-13 CN disclosed
CN-118637984-A Synthesis method of (4-chloro-naphthalene-2-yl) -methanol 埃法姆(常州)生命科学技术有限公司 2024-09-13 CN disclosed
CN-108117633-A A kind of compositions of thermosetting resin 广东生益科技股份有限公司 2018-06-05 CN disclosed
EP-2465841-A1 Preparation of esters of mono- or dicarboxylic non-aromatic and aromatic acids Lonza Ltd. (CH) 2012-06-20 EP disclosed
EP-0454501-B1 Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides SANKYO CO (JP) 2001-09-05 EP disclosed
EP-0839812-A1 Preparation of benzylthiazolidine derivatives Sankyo Company Limited (JP) 1998-05-06 EP disclosed
US-5387596-A Treating arteriosclerosis SANKYO COMPANY, LIMITED (JP) 1995-02-07 US disclosed
US-5116830-A Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses SRI INTERNATIONAL (US) 1992-05-26 US disclosed
US-4786694-A Poly(aryl ether ketone) block copolymers AMOCO CORPORATION (US) 1988-11-22 US disclosed
US-4774314-A POLYETHER KETONE POLYMERS AMOCO CORPORATION (US) 1988-09-27 US disclosed
US-4748227-A Process for preparing poly(aryl ether)ketones using a sodium carbonate/organic acid salt catalyst AMOCO CORPORATION (US) 1988-05-31 US disclosed
EP-0244167-A1 Improved process for preparing poly (aryl ethers) and poly (aryl ether ketones) AMOCO CORPORATION (US) 1987-11-04 EP disclosed
EP-0190149-A1 STEREOISOMETRICALLY PURE 17-ALPHA-ETHYNYL-ESTRA-2-EN-17BETA-OL AND ESTERS THEREOF. STANFORD RES INST INT (US) 1986-08-13 EP disclosed
EP-0182808-A1 17 a?$g(b)-HYDROXY-7$g(a)-METHYL-D-HOMO-19-NORANDROST-4,16-DIENE-3-ONE AND THE 17-ESTERS THEREOF: METHODS OF PREPARATION AND USES SRI INTERNATIONAL (US) 1986-06-04 EP disclosed
WO-1986001208-A1 STEREOISOMETRICALLY PURE 17-ALPHA-ETHYNYL-ESTRA-2-EN-17BETA-OL AND ESTERS THEREOF SRI INTERNATIONAL (US) 1986-02-27 WO disclosed
WO-1985005361-A1 17abeta-HYDROXY-7alpha-METHYL-D-HOMO-19-NORANDROST-4,16-DIENE-3-ONE AND THE 17-ESTERS THEREOF: METHODS OF PREPARATION AND USES SRI INTERNATIONAL (US) 1985-12-05 WO disclosed