Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775630 | 0.82 | ALOX5 (0.49) | MEN1KMT2AHTTMAPTLMNA | |
| SCHEMBL7150887 | 0.78 | ALOX5 (0.48) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL432482 | 0.77 | MEN1 (0.66) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL14775775 | 0.77 | PTGS1 (0.51) | PTGS1PTGS2MAOB | |
| SCHEMBL3277849 | 0.75 | MEN1 (0.68) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL23722813 | 0.73 | MEN1 (0.64) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL29540348 | 0.73 | MEN1 (0.64) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL11526406 | 0.72 | CA12 (0.66) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL28731386 | 0.72 | MEN1 (0.51) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL10702114 | 0.71 | ALOX5 (0.57) | MEN1KMT2AHTTMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240467-B1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | EVOTEC AG (DE) | 2013-03-20 | — | — | EP | claimed |