Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831632 | 0.86 | HCRTR1 (0.49) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7119865 | 0.78 | G6PD (0.47) | KDRKITFLT1MEN1USP2 | |
| SCHEMBL3825744 | 0.76 | POLB (0.46) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL15366094 | 0.73 | KCNH2 (0.46) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL975555 | 0.73 | KCNH2 (0.56) | HDAC1MAPTIKBKBPTPRFPTPN1 | |
| SCHEMBL3831610 | 0.73 | P2RY14 (0.46) | IDH2GPR35IKBKBPTPRFPTPN1 | |
| SCHEMBL3825279 | 0.73 | IDH2 (0.56) | IDH2GPR35 | |
| SCHEMBL3827067 | 0.72 | IDH2 (0.52) | IDH2 | |
| SCHEMBL3846891 | 0.72 | IDH2 (0.51) | IDH2 | |
| SCHEMBL3844021 | 0.72 | IDH2 (0.44) | IDH2MAPTGPR35IKBKBPTPRF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-B1 | INHIBITORS OF HISTONE DEACETYLASE | MERCK SHARP & DOHME (US) | 2013-03-20 | — | — | EP | disclosed |