Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TOP2A | P11388 | 9/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342871 | 0.83 | TP53 (0.61) | ATMTOP2ATP53ALOX15MEN1 | |
| SCHEMBL14775768 | 0.81 | KDM4E (0.60) | ATMTOP2ATP53ALOX15MEN1 | |
| SCHEMBL14775787 | 0.80 | TP53 (0.53) | ATMTOP2ATP53ALOX15MEN1 | |
| SCHEMBL6955977 | 0.71 | KDM4E (0.59) | MEN1KMT2AL3MBTL1PDE4DNPC1 | |
| SCHEMBL8856376 | 0.71 | ATM (0.75) | ATMTOP2AMEN1KMT2AL3MBTL1 | |
| SCHEMBL28416108 | 0.71 | ATM (0.75) | ATMTOP2AMEN1KMT2AL3MBTL1 | |
| SCHEMBL28418922 | 0.71 | ATM (0.75) | ATMMEN1KMT2APDE4DNPC1 | |
| SCHEMBL28416102 | 0.71 | ATM (0.75) | ATMTOP2ATP53MEN1KMT2A | |
| SCHEMBL26241795 | 0.70 | ATM (0.50) | ATMTP53ALOX15MEN1KMT2A | |
| SCHEMBL16171231 | 0.70 | TOP2A (0.86) | ATMTOP2AMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |