Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 8/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342871 | 0.88 | TP53 (0.61) | TP53ALOX15ATMMEN1KMT2A | |
| SCHEMBL14775768 | 0.83 | KDM4E (0.60) | TP53ALOX15ATMMEN1KMT2A | |
| SCHEMBL14775769 | 0.80 | ATM (0.56) | TP53ALOX15ATMMEN1KMT2A | |
| SCHEMBL28175303 | 0.78 | MEN1 (0.55) | ATMMEN1KMT2ATOP2AL3MBTL1 | |
| SCHEMBL15322590 | 0.78 | MEN1 (0.59) | TP53ALOX15ATMMEN1KMT2A | |
| SCHEMBL2013978 | 0.78 | HTT (0.50) | TP53ALOX15MEN1KMT2ABRD4 | |
| SCHEMBL17046868 | 0.76 | HTT (0.59) | TP53ALOX15MEN1KMT2ABRD4 | |
| SCHEMBL318630 | 0.76 | HTT (0.59) | TP53ALOX15MEN1KMT2ABRD4 | |
| SCHEMBL29577465 | 0.76 | HTT (0.59) | TP53ALOX15MEN1KMT2ABRD4 | |
| SCHEMBL554438 | 0.75 | ALDH1A1 (0.55) | MEN1KMT2AHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |