Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 10/20 | 0.59 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.58 |
| ▸ | PDE8A | O60658 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100064 | 0.93 | PDE7A (0.61) | PDE7APDE7BPDE8ASIGMAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL141195 | 0.92 | PDE7A (0.60) | PDE7APDE7BPDE8ASIGMAR1CYP3A4 | |
| SCHEMBL14775916 | 0.90 | PDE7A (0.60) | PDE7APDE7BPDE8ATSHRSIGMAR1 | |
| SCHEMBL100688 | 0.89 | PDE7A (0.56) | PDE7APDE7BPDE8ATSHRNPC1 | |
| SCHEMBL585427 | 0.88 | PDE7A (0.76) | PDE7APDE7BPDE8ATSHRKDM4E | |
| SCHEMBL173197 | 0.85 | PDE7A (0.57) | PDE7APDE7BPDE8ATSHRSIGMAR1 | |
| SCHEMBL582878 | 0.85 | PDE7A (0.57) | PDE7APDE7BPDE8ATSHRSIGMAR1 | |
| SCHEMBL3649285 | 0.85 | PDE7A (0.67) | PDE7APDE7BPDE8ATSHRNPC1 | |
| SCHEMBL474225 | 0.85 | PDE7A (0.62) | PDE7APDE7BPDE8ATSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL3752903 | 0.85 | PDE7A (0.56) | PDE7APDE7BPDE8ATSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205593-B1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-01-13 | — | — | EP | disclosed |
| EP-2416777-B1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI SA (FR) | 2014-11-12 | — | — | EP | disclosed |
| CN-102458409-B | Therapeutic applications in the cardiovascular field of quinazolinedione derivatives | SANOFI AVENTIS | 2014-06-18 | — | — | CN | disclosed |
| EP-2411009-B1 | Therapeutic uses of quinazolinedione derivatives | SANOFI SA (FR) | 2013-03-20 | — | — | EP | disclosed |
| EP-2416777-A1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI (FR) | 2012-02-15 | — | — | EP | disclosed |
| EP-2411009-A1 | THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010116090-A1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010109148-A1 | THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |
| EP-2205593-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | Sanofi-Aventis (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009077680-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI-AVENTIS (FR) | 2009-06-25 | — | — | WO | disclosed |