Upenazime

Upenazime

SCHEMBL1477985

C/C(=N\O)C(C)(C)NCCCCNC(C)(C)/C(C)=N/O

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.37
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15144439 0.98 POLB (0.36) POLBTSHRSMN1; SMN2
SCHEMBL15135657 0.98 POLB (0.36) POLBTSHRSMN1; SMN2
SCHEMBL8693325 0.95 POLB (0.37) POLBTSHRSMN1; SMN2
SCHEMBL8693335 0.95 POLB (0.37) POLBTSHRSMN1; SMN2
SCHEMBL8476517 0.90 PAOX (0.38) POLBTSHRSMN1; SMN2
SCHEMBL8476513 0.90 PAOX (0.38) POLBTSHRSMN1; SMN2
SCHEMBL26537222 0.89 POLB (0.34) POLBTSHR
SCHEMBL8476699 0.88 PAOX (0.41) POLBTSHRSMN1; SMN2
SCHEMBL8476697 0.88 PAOX (0.41) POLBTSHRSMN1; SMN2
SCHEMBL8362134 0.87 POLB (0.33) POLBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3129065-B1 TARGETED DRUG DELIVERY THROUGH AFFINITY BASED LINKERS AKAMARA THERAPEUTICS INC (US) 2026-05-13 EP disclosed
US-20250340519-A1 RADIOLABELLED COMPOUND OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2025-11-06 US disclosed
EP-4624459-A2 RADIOLABELLED COMPOUND Oxford University Innovation Limited (GB) 2025-10-01 EP disclosed
CN-118955971-A Composite film material capable of enhancing toughness of cycloolefin copolymer film and preparation method thereof 无锡阿科力科技股份有限公司 2024-11-15 CN disclosed
WO-2023165987-A1 PRECURSOR MARKERS AND RADIOTRACERS WITH THREE OR MORE TARGETING VECTORS FOR THERANOSTICS USED IN NUCLEAR MEDICINE Atoms for Cure GmbH (DE) 2023-09-07 WO disclosed
US-11701429-B2 Targeted drug delivery through affinity based linkers Akamara Therapeutics, Inc. (US) 2023-07-18 US disclosed
WO-2023118195-A1 FAP-TARGETING PHARMACEUTICAL PRODUCT FOR THERAPY AND DIAGNOSIS OF CANCERS Atoms for Cure GmbH (DE) 2023-06-29 WO disclosed
WO-2022258637-A1 TRISLINKER-CONJUGATED DIMERIC LABELLING PRECURSORS AND RADIOTRACERS DERIVED THEREFROM Atoms for Cure GmbH (DE) 2022-12-15 WO disclosed
US-11325942-B2 Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis BEIJING ARTIVILA BIOPHARMA CO. LTD. (CN) 2022-05-10 US disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
EP-1860158-B1 Particles comprising a substrate and an anion-binding layer MERCK PATENT GMBH (DE) 2013-12-04 EP disclosed
US-7914893-B2 Particles comprising an anion-binding layer containing anion-forming organic active compounds, and method of making and using thereof MERCK PATENT GMBH (DE) 2011-03-29 US disclosed
US-20070275244-A1 Particles MERCK PATENT GMBH 2007-11-29 US disclosed
EP-1860158-A2 Particles comprising a substrate and an anion-binding layer MERCK PATENT GmbH (DE) 2007-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250340519-A1 RADIOLABELLED COMPOUND PARP3, PARP2, PARP1 POLB 49/4885TSHR 1271/4885SMN1; SMN2 4502/4885
US-11701429-B2 Targeted drug delivery through affinity based linkers ABCG2, FCGR2A, ABCB1 POLB 3973/4885TSHR 2328/4885SMN1; SMN2 3007/4885
US-11325942-B2 Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis TBCA, BCL3, BCL6 POLB 3115/4885TSHR 4093/4885SMN1; SMN2 1526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.