SCHEMBL1478698

SCHEMBL1478698

O=C(O[SiH3])c1ccncn1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.52
GRM4 Q14833 4/20 0.42
CTNNB1 P35222 2/20 0.40
WNT3A P56704 2/20 0.40
FAAH O00519 1/20 0.38
TBXA2R P21731 4/20 0.38
HSP90AA1 P07900 1/20 0.35
BRD4 O60885 1/20 0.35
BRPF1 P55201 1/20 0.35
HSD17B10 Q99714 1/20 0.34
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
ABL1 P00519 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29947435 0.80 P2RX7 (0.56) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL28179627 0.80 P2RX7 (0.56) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL249470 0.80 P2RX7 (0.56) P2RX7GRM4CTNNB1WNT3AFAAH
Hydrochloric Acid SCHEMBL28392257 0.78 P2RX7 (0.55) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL27831946 0.77 P2RX7 (0.49) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL27742375 0.77 P2RX7 (0.53) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL11881388 0.77 P2RX7 (0.49) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL28171086 0.76 P2RX7 (0.61) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL1479018 0.76 P2RX7 (0.43) P2RX7GRM4CTNNB1WNT3AFAAH
SCHEMBL23293557 0.76 P2RX7 (0.47) P2RX7GRM4CTNNB1WNT3AFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103562237-B By the polymkeric substance of the carboxylicesters containing silylated amino or thiocarboxylic acid ester functional BRIDGESTONE CO.,LTD. (JP) 2016-02-17 CN claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP disclosed
US-9403919-B2 Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORPORATION (JP) 2016-08-02 US disclosed
CN-103562237-B By the polymkeric substance of the carboxylicesters containing silylated amino or thiocarboxylic acid ester functional BRIDGESTONE CO.,LTD. (JP) 2016-02-17 CN disclosed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
CN-102639568-B Functionalized polymers and methods for their manufacture BRIDGESTONE CO.,LTD. (JP) 2014-10-22 CN disclosed
EP-2699606-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP Bridgestone Corporation (JP) 2014-02-26 EP disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
CN-103562237-A Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORP 2014-02-05 CN disclosed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US disclosed
WO-2012135451-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-10-04 WO disclosed
CN-102639568-A Functionalized polymers and methods for their manufacture BRIDGESTONE CORP 2012-08-15 CN disclosed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed