SCHEMBL1478850

SCHEMBL1478850

Cc1ccc(C(=S)O[SiH3])cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
CES2 O00748 3/20 0.42
CES1 P23141 3/20 0.42
LMNA P02545 2/20 0.42
TDP1 Q9NUW8 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
HPGD P15428 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
ACHE P22303 2/20 0.38
PKM P14618 2/20 0.38
HTT P42858 2/20 0.38
ATM Q13315 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
NLRP1 Q9C000 1/20 0.38
GAA P10253 1/20 0.38
NTSR1 P30989 1/20 0.38
HDAC1 Q13547 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9436697 0.78 TDP1 (0.54) ALDH1A1CES2CES1LMNATDP1
SCHEMBL1478331 0.75 MAPT (0.41) ALDH1A1CES2CES1LMNATDP1
SCHEMBL27922085 0.74 KMT2A (0.42) ALDH1A1CES2CES1LMNATDP1
SCHEMBL12813996 0.74 FAAH (0.47) ALDH1A1TDP1SMN1; SMN2HPGDACHE
SCHEMBL1479349 0.73 SMN1; SMN2 (0.43) ALDH1A1LMNASMN1; SMN2NPC1RAB9A
SCHEMBL28488730 0.71 ALDH1A1 (0.42) ALDH1A1CES2CES1LMNATDP1
SCHEMBL1479497 0.71 NAPRT (0.41) ALDH1A1LMNATDP1SMN1; SMN2HPGD
SCHEMBL1478489 0.71 TDP1 (0.64) ALDH1A1CES2CES1LMNATDP1
SCHEMBL7767010 0.71 ALDH1A1 (0.39) ALDH1A1CES2CES1LMNATDP1
SCHEMBL4460667 0.71 ALDH1A1 (0.52) ALDH1A1CES2CES1LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP claimed
CN-103562237-B By the polymkeric substance of the carboxylicesters containing silylated amino or thiocarboxylic acid ester functional BRIDGESTONE CO.,LTD. (JP) 2016-02-17 CN claimed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP claimed
CN-103562237-A Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORP 2014-02-05 CN claimed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US claimed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP claimed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US claimed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP disclosed
US-9403919-B2 Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORPORATION (JP) 2016-08-02 US disclosed
CN-103562237-B By the polymkeric substance of the carboxylicesters containing silylated amino or thiocarboxylic acid ester functional BRIDGESTONE CO.,LTD. (JP) 2016-02-17 CN disclosed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
CN-102639568-B Functionalized polymers and methods for their manufacture BRIDGESTONE CO.,LTD. (JP) 2014-10-22 CN disclosed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US disclosed
WO-2012135451-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-10-04 WO disclosed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed