Sugi Predict

Sugi Predict / Compounds / SCHEMBL1478925

SCHEMBL1478925

SCHEMBL1478925

COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)NC5CC5)cc4F)c3s2)nc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 10/20 0.73
▸ KDR P35968 10/20 0.73
▸ AXL P30530 2/20 0.73
▸ FLT3 P36888 2/20 0.73
▸ NTRK1 P04629 1/20 0.73
▸ KIT P10721 1/20 0.73
▸ NTRK2 Q16620 1/20 0.73
▸ MST1R Q04912 12/20 0.71
▸ PLK4 O00444 1/20 0.71
▸ MAP4K4 O95819 1/20 0.71
▸ ABL1 P00519 1/20 0.71
▸ LCK P06239 1/20 0.71
▸ FYN P06241 1/20 0.71
▸ LYN P07948 1/20 0.71
▸ HCK P08631 1/20 0.71
▸ PDGFRB P09619 1/20 0.71
▸ BCR P11274 1/20 0.71
▸ SRC P12931 1/20 0.71
▸ ABL2 P42684 1/20 0.71
▸ FRK P42685 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1478713 0.97 MET (0.72) METKDRAXLFLT3NTRK1
SCHEMBL1478899 0.94 MET (0.76) METKDRAXLFLT3NTRK1
Hydrochloric Acid SCHEMBL1479074 0.93 MET (0.75) METKDRAXLFLT3NTRK1
SCHEMBL2532322 0.92 MET (0.77) METKDRAXLFLT3NTRK1
SCHEMBL2671038 0.91 MET (0.74) METKDRAXLFLT3NTRK1
SCHEMBL1478572 0.91 MET (0.74) METKDRAXLFLT3NTRK1
SCHEMBL106696 0.91 MET (0.85) METKDRAXLFLT3NTRK1
SCHEMBL2671025 0.91 MET (0.73) METKDRAXLFLT3NTRK1
SCHEMBL2535014 0.91 MET (0.74) METKDRAXLFLT3NTRK1
SCHEMBL2670766 0.90 MET (0.77) METKDRAXLFLT3NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140179632-A1 METHODS OF INHIBITING PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2014-06-26 — — US disclosed
US-8759522-B2 Inhibitors of protein tyrosine kinase activity METHYLGENE INC. (CA) 2014-06-24 — — US disclosed
US-8759522-B2 Inhibitors of protein tyrosine kinase activity METHYLGENE INC. (CA) 2014-06-24 — — US disclosed
US-8729268-B2 Inhibitors of protein tyrosine kinase activity METHYLGENE INC. (CA) 2014-05-20 — — US disclosed
US-20110098293-A1 Inhibitors of Protein Tyrosine Kinase Activity OTSUKA PHARMACEUTICAL CO. LTD. (JP) 2011-04-28 — — US disclosed
US-20110098293-A1 Inhibitors of Protein Tyrosine Kinase Activity OTSUKA PHARMACEUTICAL CO. LTD. (JP) 2011-04-28 — — US disclosed
US-20110077240-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2011-03-31 — — US disclosed
US-20110077240-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2011-03-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140179632-A1 METHODS OF INHIBITING PROTEIN TYROSINE KINASE ACTIVITY PTK2B, PRKACA, DSTYK MET 240/4885KDR 70/4885AXL 341/4885
US-20110077240-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY ABL1, ERBB2, TYRO3 MET 111/4885KDR 8/4885AXL 82/4885
US-20110098293-A1 Inhibitors of Protein Tyrosine Kinase Activity ABL1, ERBB2, TYRO3 MET 111/4885KDR 8/4885AXL 82/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.