Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 17/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 17/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 17/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 16/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 16/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 16/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 16/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12879075 | 0.86 | PRKAG1 (0.46) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL1963463 | 0.82 | PRKAG1 (0.56) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL4008217 | 0.82 | PRKAG1 (0.56) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL1406065 | 0.81 | MAP2K4 (0.61) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL260615 | 0.81 | PDPK1 (0.61) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL953396 | 0.81 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL956608 | 0.81 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL570293 | 0.81 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL1963276 | 0.78 | PRKAG1 (0.52) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 | |
| SCHEMBL5945655 | 0.78 | PRKAA1 (0.72) | PRKAG1PRKAA1PRKAB1HAO1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013040215-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | SAMUMED, LLC (US) | 2013-03-21 | — | — | WO | disclosed |