Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27499331 | 0.83 | SLC6A2 (0.33) | SLC6A2HTR2AHTR2CSLC6A4HTR7 | |
| SCHEMBL27528376 | 0.81 | SLC6A2 (0.33) | SLC6A2HTR2AHTR2CSLC6A4HTR7 | |
| SCHEMBL14795233 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5039030 | 0.79 | SLC6A2 (0.32) | SLC6A2HTR2AHTR2CSLC6A4HTR7 | |
| Hydrochloric Acid SCHEMBL5040217 | 0.79 | SLC6A2 (0.32) | SLC6A2HTR2AHTR2CSLC6A4HTR7 | |
| Bromide SCHEMBL11401473 | 0.77 | SLC6A4 (0.35) | SLC6A2HTR2AHTR2CSLC6A4HTR7 | |
| SCHEMBL11470901 | 0.76 | NPC1 (0.45) | SLC6A2HTR2AHTR2CSLC6A4HTR7 | |
| SCHEMBL21810782 | 0.75 | — | — | |
| SCHEMBL18097667 | 0.75 | — | — | |
| SCHEMBL25155794 | 0.74 | SLC6A2 (0.36) | SLC6A2HTR2AHTR2CSLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4246262-A | ANTIBIOTICS | LEO PHARMACEUTICAL PRODUCTS, LTD. A/S (DK) | 1981-01-20 | — | — | US | disclosed |